OCT for 3D cell culture visualization

White Paper / Medical technology /

Challenges and potential solutions for 3D cell cultures visualization

Cell cultures that grow in a three-dimensional form offer clear advantages for drug research: due to their higher complexity compared to simpler single-layer cell cultures, they better represent the conditions of the human body. This opens new opportunities, particularly in drug research: Between 88 and 95 percent of all drugs in clinical trials never reach the market because the results of tests on 2D cell cultures cannot be reproduced in clinical trials. Because 3D cell cultures can better replicate what happens in the human body, they create a more realistic environment for drug testing. This could bring more drugs to market in the future and significantly reduce the development costs of new drugs. In this white paper, we describe the challenges of visualizing 3D cell cultures and how optical coherence tomography (OCT) can be used to reliably visualize them.